منابع مشابه
The stereochemistry of complex polyketide biosynthesis by modular polyketide synthases.
Polyketides are a diverse class of medically important natural products whose biosynthesis is catalysed by polyketide synthases (PKSs), in a fashion highly analogous to fatty acid biosynthesis. In modular PKSs, the polyketide chain is assembled by the successive condensation of activated carboxylic acid-derived units, where chain extension occurs with the intermediates remaining covalently boun...
متن کاملEvolution of polyketide synthases in bacteria.
The emergence of resistant strains of human pathogens to current antibiotics, along with the demonstrated ability of polyketides as antimicrobial agents, provides strong motivation for understanding how polyketide antibiotics have evolved and diversified in nature. Insights into how bacterial polyketide synthases (PKSs) acquire new metabolic capabilities can guide future laboratory efforts in g...
متن کاملMicrobial polyketide synthases: more and more prolific.
Microorganisms make a wealth of unusual metabolites that have a secondary role in the organism’s ontogeny, such as self-defense, aggression, or even communication as the need arises. These compounds often have biological activity valuable to humankind (1). Nevertheless, as valuable as antibiotics and other naturally occurring drugs have been over the past 60 years, their future use is threatene...
متن کاملEvolutionary implications of bacterial polyketide synthases.
Polyketide synthases (PKS) perform a stepwise biosynthesis of diverse carbon skeletons from simple activated carboxylic acid units. The products of the complex pathways possess a wide range of pharmaceutical properties, including antibiotic, antitumor, antifungal, and immunosuppressive activities. We have performed a comprehensive phylogenetic analysis of multimodular and iterative PKS of bacte...
متن کاملEmergent colinearity in a model of modular polyketide synthases
Polyketides are widespread, biologically active heteropolymers assembled by complexes of modular polyketide synthase(PKS) proteins. We implement a model of this system and explore its evolutionary behavior while subject to recombination in a changing environment. Under appropriate population parameters the combinatorial exploration of novelty allows a finite population to maintain high fitness ...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2004
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2004.01.005